HGH otherwise known as growth hormone is a peptide that contains about 190 amino acids that stimulate the creation of various factors of growth such as insulin-like growth factor 1, that is, IGF-1. These in turn promote the growth of various tissues such as connective tissue, viscera, muscle and skeleton.
In addition they encourage physiological activities such as protein synthesis, increasing nucleic acid and lipolysis. However, urea secretion is discouraged.
The hormone that is secreted in huge amounts by the anterior pituitary gland is HGH, that is, human growth hormone. Cells of the immune system, for instance, lymphocytes and macrophages also secrete and produce growth hormone.
What the GH does is that it rouses the liver to produce somatomedins. These have the effect of promoting the growth of:
When HGH is not taken in moderation and under supervision from a qualified doctor, there are numerous side effects that a person can suffer from.
Recombinant HGH therapy has numerous side effects that are well documented. Some of the negative effects that are associated with the synthetic replacement of HGH via injections include:
- Development of HGH antibodies
- Water retention
- Insulin resistance
- Carpal Tunnel Syndrome
- Reduced life span
- Abnormal growth of bones
- Agitated insulin metabolism
- Overgrowth of connective tissue
Research study shows that by administering compounds that increase the release of growth hormones in the body, there is a significant increase in milk production in addition to having an enhanced body weight. These are some of the effects that will be experienced if one is able to achieve sufficient levels of growth hormones in their body after they have administered the GH-releasing compounds.
By administering higher than normal levels of HGH into your body, you expose yourself to the dangers of the negative side effects that are associated with excessive amounts of HGH. Some of these side effects include:
- Tissue turgor
- Back pain
- Increase in liver enzymes such as alanine aminotransferase SPGT and aspartate aminotransferase SGOT
- Joint and skin problems
- Increased sweating
The lateral anterior pituitary gland produces and secretes growth hormones through the somatomammotrophic and somatotrophic cells..The contol of both growth hormone secretion and production is a bit complex, but is primarily under the control of somatostatin and growth hormone releasing hormone, that is, GHRH. These two inhibit and stimulate it respectively.
Regulation of HGH in our Bodies
Once a synthetic growth hormone has been administered into the body, high levels of somatostatin are triggered by the hypothalamus. Somatostatin is an inhibitor of growth hormone release. In turn the pituitary gland is prompted to cease producing HGH. The release of natural HGH by the pituitary gland is controlled through negative feedback which involves both release inhibiting and growth hormone releasing factors.
Whenever the growth hormone levels in our bodies are below a sufficient amount, the pituitary gland produces more HGH after being stimulated by releasing factors that are found in the hypothalamus. If ever our bodies have a high amount of growth hormones, the hypothalamus through somatostatin, a release inhibiting factor, inhibits the pituitary gland from releasing natural HGH.
For this reason, any addition of growth hormones into our body systems either synthetic or natural will have an effect on the negative feedback process. This will in turn disrupt the growth hormone balance in our system that is achieved by both the pituitary gland and the hypothalamus. Due to this, the pituitary gland may slow down in its production of HGH or completely shut down in regard to producing HGH.
Chronic rise in HGH levels in our body system has adverse effects and leads to certain health conditions such as acromegaly and gigantism. For patients who suffer from acromegaly, they further get exposed to other conditions such as myopathy which leads to hypertrophy and pathology. The good news however is that extremity bones and enlarged facial features can be remedied through the administration of an effective GH-RH antagonist.
Due to the many risk factors that are associated with synthetic HGH injections, it is recommended that people suffering from an HGH deficiency take them.
Before taking any HGH products you should make the effort of seeing a well qualified doctor for a medical checkup.